När Sabrina flyttar till Riverdale kommer hon underfund med att hon är en häxa. Under vakande ögon från fastrarna Hilda och Zelda, som också är häxor, skall Sabrina nu lära sig vad hon kan använda sina häx-konster till - på gott och ont. När hennes två världar kolliderar, är Sabrina den enda som klarar av att kämpa mot sina fiender, samtidigt som hon försöker hålla sin hemliga identitet som häxa dold för alla människor runt omkring henne.
Sabrina takes a holiday idea from Salem and brings her friends on the spooky Mystery Train for a Halloween adventure. There's just one problem: It's in the Other Realm. Sabrina soon learns that the mortals can leave only if she solves the puzzling mystery when she goes back into something out of a 1920 mystery movie.
Sabrina and Roxie get their own call in college radio show. Sabrina is tongue tied while Roxie takes right to it. Sabrina then bows out and lets Roxie have the show.
Josh gets Sabrina a job at the newspaper, but she wants to keep their relationship a secret so people don't think she got the job as the photographer's girlfriend.
When Sabrina tries to say "I Love You" after Josh professes his love, it comes out in a funny voice. The Love Doctor says that she has to tell him that she is a witch.
Great-aunt Irma shows up with a witch named Peter that Sabrina is supposed to marry immediately. Peter doesn't want to get married and falls for Roxie.
Sabrina is annoyed when Josh says that women can't play tennis so she gets professional and magical help. Zelda and Hilda coach Amanda for her witch's license.