The Great North volgt de avonturen van de familie Tobin in Alaska, waar alleenstaande vader Beef zijn best doet om zijn rare kinderen bij zich in de buurt te houden. In het bijzonder zijn enige dochter Judy, met haar artistieke dromen die haar weghalen van de vissersboot van de familie en meevoeren naar de glamoureuze wereld van het plaatselijke winkelcentrum. De andere leden van de familie zijn Judy’s oudere broer Wolf en zijn verloofde Honeybee, haar middelste broer Ham en haar tienjarige, vroegwijze broertje Moon. Terwijl hun moeder buiten beeld is, zoekt Judy steun bij haar nieuwe bazin Alyson en haar denkbeeldige vriendin Alanis Morissette, die aan haar verschijnt in het noorderlicht.
While Beef is away, the Tobin fishing boat goes missing! The Tobin siblings, along with Honeybee and Dirt, wildly speculate on what could have happened to The Mighty Kathleen.
Wolf finally gets cast on the local Alaskan survival show Dropped Off To Die, but when he's out early, his shame leads him to sneak home and hide on the Tobin property instead.
Ham starts performing at Yet-E-Cheddar's and develops a strange relationship with an animatronic Freddie the Yeti, that puts his relationship with Crispin in jeopardy. When the new Tobin Boat turns out to have a cursed name, the kids battle, Succession-style, for naming rights. Ham and Crispin break up.
Principal Gibbons catches Aunt Dirt posing as a cafeteria worker to woo another lunch lady and offers her the job if she agrees to coach the debate team; Wolf endeavors to impress Beef.
Judy feels anxiety about growing apart from Moon, so she signs them up for something they loved doing when they were younger, ice dance competitions. Beef is taken aback when Zelda Blop moves in next door.
On a field trip to view Curlew's Kissin' Comets, Beef rushes to stop his kids from suffering a terrible fate. Aunt Dirt goes rogue at the Old Moose Retirement Home.
