Vào lần sinh nhật lần thứ 16 của mình, cô phát hiện mình có phép thuật và là một phù thủy. Cô sống với hai người cô "800 tuổi" nhưng lại rất vui vẻ và không kém phần kì quặc của mình. Đó là Hilda Spellman (do Caroline Rhea thủ vai) và Zelda Spellman (do Beth Broderick đóng), cùng với chú mèo biết nói Salem Saberhagen (lồng tiếng bởi Nick Bakay) sống tại một thị trấn " Chỉ có ở phim " tại Westbridge, Massachusetts.
Sabrina learns that she has been instructed to mentor a witch student, and it turns out that her student is the new girl at school, Dreama. However, Dreama's clumsy spells arouse Harvey's friend Brad's suspicions, revealing his true nature.
Sabrina turns green with envy, literally, after Harvey and Brad become best friends, triggering a case of Jealotosis - an intense green-eyed witch envy - when Harvey teams up with Brad instead of her to write an article for the school paper.
Sabrina zaps on a skin cream to appear more mature after college-guy Josh shoots down a romance because of her age, but the fast-acting lotion ends up being a rapid-aging potion.
Consumed with guilt over kissing Josh, Sabrina runs herself ragged trying to cook up a way to get Harvey to forgive her without having to say she's sorry.
Sabrina and Mrs. Quick uncover a scandal at school involving Mr. Kraft and misappropriated funds. Meanwhile, Sabrina finds Salem a date for his high school reunion, but it seems he is much more interested in her than she is in him.
When Sabrina is accepted to different colleges, she is pressured by Josh, Harvey and Zelda to choose their favorite, but her indecisiveness and need to please everyone causes her to be torn apart -- literally into four different Sabrinas.