Vào lần sinh nhật lần thứ 16 của mình, cô phát hiện mình có phép thuật và là một phù thủy. Cô sống với hai người cô "800 tuổi" nhưng lại rất vui vẻ và không kém phần kì quặc của mình. Đó là Hilda Spellman (do Caroline Rhea thủ vai) và Zelda Spellman (do Beth Broderick đóng), cùng với chú mèo biết nói Salem Saberhagen (lồng tiếng bởi Nick Bakay) sống tại một thị trấn " Chỉ có ở phim " tại Westbridge, Massachusetts.
Sabrina can't understand boys and when she senses something between Harvey and Valerie, she turns herself into a boy but ends up dating Libby. Hilda also transforms into a man to try and get rid of Mr Kraft.
After Sabrina's country cousins express their anger over Sabrina getting the family spell book, they magically lock the Spellmans and their guests in the house.
On Friday the 13th a witch can tell a mortal about being a witch because at the end of the day they will forget about their secret so Sabrina tells Valerie and Harvey.
While working on a float with Libby, Sabrina casts a spell that keeps her away from Sabrina. The spell is reversed and they have to spend time together. Finally Libby turns into a puzzle that Sabrina has to solve.
Sabrina erases her fears before reading an essay in front of a school assembly and her fears stalk the the school halls causing everyone to be afraid of the smallest things.
On a field trip to Disney's Animal Kingdom in Florida, Sabrina, working to pass a critical test for her witch's license, accidentally turns Libby and Valerie into zebras.
In order to get her witch's license, Sabrina must complete community service in the Other Realm. She gets a job at the rumor mill, a place where rumors are started, and meets a guy named Dashiell.
Sabrina's plan to balance seeing both Harvey and Dashiell is disrupted when they meet each other by chance. They ask her to choose between them, while a hasty act leads to her being forced to make an even bigger decision.