After a mysterious school opens across the street, the students of Super Hero High find themselves up against a new threat. Now, Wonder Woman, Supergirl, Batgirl and the rest of the DC Super Hero Girls not only have to worry about the well-being of their grades, but the safety and security of friends, family and the rest of civilization. The girls must figure out how to put a stop to this evil, new cross-town rival and save the world once again