Johnny Mack Brown follows his tried-and-true western formula in Law of the Panhandle. This time, U.S. Marshal Brown backs up Sheriff Tom Stocker (Riley Hill) in an ongoing battle against a marauding outlaw gang. The thieves, led by snarling Henry Faulkner (Myron Healey), hope to scare all the local ranchers off the land that will soon be purchased by the railroad that's coming through the territory.